Ca²⁺ transients in bladder small DRG neuron soma model.

<p>(A) Comparison of normalized Ca²⁺ transient obtained from bladder small DRG neurons experimentally (circles, Expt. Calcium Transient, [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006293#pcbi.1006293.ref111" target="_blank">111</a>] obtained from fluorescence studies) and our model (Solid line, Sim. Calcium Transient) by application of high [K]_o (30 mM) for 50 seconds (indicated by bar). The S value for the fit and the 5% threshold (in brackets) is 0.2 (0.05). (B) Ca²⁺ transient for a single AP in the model. AP was generated by 2 nA, 1 ms rectangular current clamp pulse. The model was held at −80 mV for 50 ms before generating the AP. The data for resting [Ca]_i and change in [Ca]_i (Δ[Ca]_i) was obtained from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006293#pcbi.1006293.ref044" target="_blank">44</a>] for small DRG neurons. Effects of calcium dye buffering were included in the simulations.