<p>Top Row: The proportion of polymorphic sites where a mutant allele represents a change towards the (subtype-specific) population consensus. Bottom Row: The bias in changes towards population consensus. This is the ratio of the proportion of changes that are towards (subtype-specific) population consensus, compared to the expected proportion in the absence of selection, measured at polymorphic sites and with an assumed mutational transition to transversion ratio of two. A bias of 1 means the proportion of changes that are towards population consensus matches the expectation. The error bars give the 5 and 95 percentiles from 10,000 bootstraps of the individual data. Black, all changes; Blue, synonymous changes; Red, nonsynonymous changes.<...
<p><sup>a</sup> The listed resistant strain was mated with the isogenic sensitive strain of the oppo...
<p>Significant differences between rates in young singletons as compares to the other two datasets a...
<p>The dark gray bars (left) represent the mean final fitness of populations that evolve under each ...
Symbols represent transition:transverion ratios (Basel paths: 74:78, empirical P value = 7.1 × 10−5;...
<p>Dark grey are populations evolved in the benign environment and light grey are the populations ev...
<p>Relative biases are plotted as a function of the coefficient of variation . The different curves ...
<p>A.) Pairwise F<sub>ST</sub> of polymorphic sites. Each patient sample was treated as a population...
Median estimates of the expected population proportions of positively selected nonsynonymous mutatio...
<p>The results shown are for the diploid method with , for peak 0 (a, left) and peak 1 (b, right). I...
<p>For each function <i>f</i>, the bars indicate the percentage (%) of disease mutations that have a...
<p>The X-axis shows the ratio of the number of substitutions in functional, relative to control site...
Proportion of minority variants detected by Next-Generation Sequencing. The proportion of mutations ...
<p>Points correspond to the mean over 10<sup>4</sup> simulations, error-bars correspond to the 95% c...
<p>ML estimates and their 95% confidence intervals are based on the observed number of unique mutati...
When a selectively favourable gene substitution occurs in a population, changes in gene frequencies ...
<p><sup>a</sup> The listed resistant strain was mated with the isogenic sensitive strain of the oppo...
<p>Significant differences between rates in young singletons as compares to the other two datasets a...
<p>The dark gray bars (left) represent the mean final fitness of populations that evolve under each ...
Symbols represent transition:transverion ratios (Basel paths: 74:78, empirical P value = 7.1 × 10−5;...
<p>Dark grey are populations evolved in the benign environment and light grey are the populations ev...
<p>Relative biases are plotted as a function of the coefficient of variation . The different curves ...
<p>A.) Pairwise F<sub>ST</sub> of polymorphic sites. Each patient sample was treated as a population...
Median estimates of the expected population proportions of positively selected nonsynonymous mutatio...
<p>The results shown are for the diploid method with , for peak 0 (a, left) and peak 1 (b, right). I...
<p>For each function <i>f</i>, the bars indicate the percentage (%) of disease mutations that have a...
<p>The X-axis shows the ratio of the number of substitutions in functional, relative to control site...
Proportion of minority variants detected by Next-Generation Sequencing. The proportion of mutations ...
<p>Points correspond to the mean over 10<sup>4</sup> simulations, error-bars correspond to the 95% c...
<p>ML estimates and their 95% confidence intervals are based on the observed number of unique mutati...
When a selectively favourable gene substitution occurs in a population, changes in gene frequencies ...
<p><sup>a</sup> The listed resistant strain was mated with the isogenic sensitive strain of the oppo...
<p>Significant differences between rates in young singletons as compares to the other two datasets a...
<p>The dark gray bars (left) represent the mean final fitness of populations that evolve under each ...