<p>Significant differences between rates in young singletons as compares to the other two datasets are annotated (Z-test, Bonferroni corrected). Error bars indicate S.E. * indicated <i>p</i><0.05, ** indicate <i>p</i><0.01, *** indicate <i>p</i><0.001.</p
<p>Cm<sup>R</sup> emergence rates of wild-type derivative strains relative to Wt-X1 strain (blue bar...
<p>For each variant the relative activity at Aβ divided by the relative activity on the off target p...
<p>Data is represented as column graph depicting mean value of scores for each group of patients. Er...
The average measured mutation frequency across all five mutations is plotted against the average exp...
<p>Mutation rates for a total of 147 BPS mutations normalized to the number of A, T, G or C base pai...
<p>ML estimates and their 95% confidence intervals are based on the observed number of unique mutati...
<p>Error bars give standard errors. We cannot reject a mean effect of zero for addition of either mu...
<p>Data are mean ± SEM.</p><p>Mutation rates are expressed as mutations per microsatellite per gener...
<p>A: Gene location of mutations. Data are represented as the percentage of the total coding region ...
<p>The boxes span the lower and upper quartile with the median indicated by a red bar; whiskers exte...
Transitions are indicated with bold text. Rates adjusted for GC content (Materials and methods).</p
<p>Top Row: The proportion of polymorphic sites where a mutant allele represents a change towards th...
<p>Relative biases are plotted as a function of the coefficient of variation . The different curves ...
Symbols represent transition:transverion ratios (Basel paths: 74:78, empirical P value = 7.1 × 10−5;...
<p>In all parts of the figure, the sample points, box-and-whisker plots and the symbols for the <i>P...
<p>Cm<sup>R</sup> emergence rates of wild-type derivative strains relative to Wt-X1 strain (blue bar...
<p>For each variant the relative activity at Aβ divided by the relative activity on the off target p...
<p>Data is represented as column graph depicting mean value of scores for each group of patients. Er...
The average measured mutation frequency across all five mutations is plotted against the average exp...
<p>Mutation rates for a total of 147 BPS mutations normalized to the number of A, T, G or C base pai...
<p>ML estimates and their 95% confidence intervals are based on the observed number of unique mutati...
<p>Error bars give standard errors. We cannot reject a mean effect of zero for addition of either mu...
<p>Data are mean ± SEM.</p><p>Mutation rates are expressed as mutations per microsatellite per gener...
<p>A: Gene location of mutations. Data are represented as the percentage of the total coding region ...
<p>The boxes span the lower and upper quartile with the median indicated by a red bar; whiskers exte...
Transitions are indicated with bold text. Rates adjusted for GC content (Materials and methods).</p
<p>Top Row: The proportion of polymorphic sites where a mutant allele represents a change towards th...
<p>Relative biases are plotted as a function of the coefficient of variation . The different curves ...
Symbols represent transition:transverion ratios (Basel paths: 74:78, empirical P value = 7.1 × 10−5;...
<p>In all parts of the figure, the sample points, box-and-whisker plots and the symbols for the <i>P...
<p>Cm<sup>R</sup> emergence rates of wild-type derivative strains relative to Wt-X1 strain (blue bar...
<p>For each variant the relative activity at Aβ divided by the relative activity on the off target p...
<p>Data is represented as column graph depicting mean value of scores for each group of patients. Er...
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