Percentage of disease variants with prediction scores at the 1% false positive rate threshold in putatively neutral variants.

<p>For each function <i>f</i>, the bars indicate the percentage (%) of disease mutations that have a greater and than a conservative threshold at 1% false positive rates (FPR). These thresholds are estimated from the null distributions of and on the set of dbSNP neutral data, respectively. *Indicates significant <i>p</i>-value measured as a one-tailed Fisher’s Exact test after Bonferroni correction for multiple hypothesis testing (<i>p</i> < 8.62 ⋅ 10⁻⁴). The red line indicates the percentage of neutral variants that have greater and which is exactly 1%.