Preparation of protein nanoparticle by dynamic aggregation and ionizing-induced crosslinking

Achilli, Estefanía Edith
Casajus, Gonzalo
Siri, Macarena
Flores, Constanza Yanel
Kadlubowski, S.
Alonso, Silvia del Valle
Grasselli, Mariano

Open link

Publication date

December 2015

DOI

10.1016/j.colsurfa.2015.09.047

Publisher

Elsevier BV

ISSN

0927-7757

Journal

Colloids and Surfaces A Physicochemical and Engineering Aspects

Citation count (estimate)

Abstract

Globular proteins can be considered as nanotools useful to perform a variety of chemical reactions. These biological macromolecules have very complex and detailed topological characteristics responsible for their several functions, which can be used for technological applications.Albumin is one of the few commercially available proteins with potential use in the preparation of nanomaterials by the bottom-up strategy. Albumin nanoparticles (NPs) can be prepared by several methods, but the preservation of the structure of the native protein in the final structure has not yet received too much attention.Our research group has recently reported the use of ionizing radiation to obtain albumin NPs. The irradiation of an ethanol solution of bovine...