Correlation between assembly structure of a gamma irradiated albumin nanoparticle and its function as a drug delivery system
- Siri, Macarena
- Grasselli, Mariano
- Alonso, Silvia del Valle
DOIAbstract
The present study correlates the structure of an albumin nanoparticle with its function as a drug delivery system. The albumin nanoparticle was created by a clean and size-controlled desolvation method in combination with gamma irradiation as a cross-linker. It is composed of 3950 albumin molecules with a molecular weight of 5.78E + 02 MDa and the binding between the albumin molecules creates new hydrophobic pockets. Our hypothesis was that the very assembly structure of the nanoparticle played a key role in making it a suitable drug delivery system. In order to study how the assembly of the nanoparticle enhanced its function as such, we used a hydrophobic drug, Emodin. The high affinity of the nanoparticle for the drug was studied with spe...
Add to ORKG