<i>Bhlhe40</i> KO mice have increased neuronal excitability.

<p>(A) <i>Bhlhe40</i> KO mice have a 14.4% decrease in IPSC amplitude (<i>Bhlhe40</i> KO: 85.6 ± 12.2, WT: 100 ± 11.6); n = 4 mice for each <i>Bhlhe40</i> KO (5 cells) and WT (6 cells). (B) Left: <i>Bhlhe40</i> KO mice have a 40% increase in mEPSC amplitude, relative to WT levels (<i>Bhlhe40</i> KO: 18.99 ± 0.69 pA, WT: 13.6 ± 0.88 pA). Right: Example traces of mEPSCs from WT and <i>Bhlhe40</i> KO slices. Error bars are standard error of the mean; unpaired t-tests were used for both mEPSC and IPSC amplitude comparisons <i>Bhlhe40</i> KO hippocampal slices compared to WT slices; * = p<0.05.