Improved hippocampal synaptic plasticity in Liver-PtenKO mouse model.

Input/Output (I/O) and LTP changes were measured in both groups. (A) Representative I/O curves for both groups at increasing stimulus intensities, and I/O slope values at increasing stimulus intensities. (B) Average I/O curve slopes for both groups at 400 μA. (C) LTP induced at baseline intensity using theta burst stimulation (TBS) consisting of ten trains of five 100 Hz stimulation repeated at 5 Hz. Slope of EPSPs was measured and results normalized to the average value measured during the 10 min baseline period. (D) Average of the last 5 min of recordings post-TBS, which is considered as LTP. Total n = 20 slices; n = 10 slices/group and at n = 4 animals/group. Statistical significance calculated using paired student t-test (*P ≤ 0.05; **P ≤ 0.01). Error bars indicate ± SD.