<i>Bhlhe40</i> KO mice have reduced hippocampal synaptic plasticity.

<p>(A) EPSP slope input/output curves were significantly different (p<0.001; n = 9). (B) Paired pulse facilitation is not significantly impaired (p = 0.063; n = 5). (C) There was a 60% reduction in LTP measured by EPSP slope 1hr following 1s of 100Hz stimulation (<i>Bhlhe40</i> KO: 120 ± 20.7%, WT: 150.5 ± 21%; p<0.001; n = 5 mice, 6 slices each). (D) There was a 52% reduction in LTD measured by EPSP slope 1hr following 15min of 1Hz stimulation (<i>Bhlhe40</i> KO: 85 ± 12.8%, WT: 68.5 ± 19.5%; p<0.001; n = 5 mice, 6 slices each). Data from Figs 3A, 3B, 3C, and 3D were p<0.05 on Shapiro Wilk normality test and tested for significance by Mann-Whitney Rank Sum Test. Error bars are standard error of the mean.