<p>Six and half months old female NZB/W F<sub>1</sub> mice were orally treated with vehicle (saline), SM934 (10, 3, and 1 mg/kg, respectively), and PNS (2 mg/kg) for 3 months (n = 11 per group). Left, representative kidney sections stained with H&E (Original magnification×200); Right, representative immunofluorescence staining of IgG deposit in the kidney sections (Original magnification×100).</p
OBJECTIVE: To investigate the efficacy of different doses of the soluble form of the receptor for a...
<p>(<b>A</b>) Representative images of 4-hydroxy-2-nonenal (4-HNE) immunostaining in the kidneys of ...
<p>(A), Albuminuria data for mice in saline (n=13), Dex (n=13), and P-Dex (n=9) treatment groups is ...
<p>Six and half months old female NZB/W F<sub>1</sub> mice were orally treated with vehicle, SM934 (...
<p>(A), Representative images of immunohistochemical staining of kidney sections from mice in the sa...
<p>Six and half months old female NZB/W F<sub>1</sub> mice were orally treated with vehicle (saline)...
<p>(A) Protein concentrations of 24 h-urine from iguratimod treated and control mice. Each dot repre...
<p>6–8 week old WT mice were treated with the Sphk2 inhibitor (SK2i) at 3mg/kg. Renal injury was ass...
<p>(A) Serum samples from 8 month old female B6, B6.NZBc1, B6.NZBc13, B6.NZBc1c13 and NZB mice were ...
<p>*p<0.05.</p><p>Renal histopathology scores for saline or MDL72527 treated mice subjected to Sham ...
<p>Representative images of HE-stained (A, 400×), PAS-stained (B, 400×), Immunofluorescence (C, 200×...
Frozen sections of kidneys from a one year old non-transgenic C57BL/6 mouse and from three thirteen ...
<p><i>129/svj</i> mice were challenged with anti-GBM antibody on day 0 and then treated with hKLK1-M...
<p>(A) Male WT, PAI-1<sup>−/−</sup>, and PAI-1<sup>R101A/Q123K</sup> mice were assessed for kidney i...
<p>(<b>A</b>) The intensity of proteinuria was scored on a 0 to 4 scale. Mean results are shown. (<b...
OBJECTIVE: To investigate the efficacy of different doses of the soluble form of the receptor for a...
<p>(<b>A</b>) Representative images of 4-hydroxy-2-nonenal (4-HNE) immunostaining in the kidneys of ...
<p>(A), Albuminuria data for mice in saline (n=13), Dex (n=13), and P-Dex (n=9) treatment groups is ...
<p>Six and half months old female NZB/W F<sub>1</sub> mice were orally treated with vehicle, SM934 (...
<p>(A), Representative images of immunohistochemical staining of kidney sections from mice in the sa...
<p>Six and half months old female NZB/W F<sub>1</sub> mice were orally treated with vehicle (saline)...
<p>(A) Protein concentrations of 24 h-urine from iguratimod treated and control mice. Each dot repre...
<p>6–8 week old WT mice were treated with the Sphk2 inhibitor (SK2i) at 3mg/kg. Renal injury was ass...
<p>(A) Serum samples from 8 month old female B6, B6.NZBc1, B6.NZBc13, B6.NZBc1c13 and NZB mice were ...
<p>*p<0.05.</p><p>Renal histopathology scores for saline or MDL72527 treated mice subjected to Sham ...
<p>Representative images of HE-stained (A, 400×), PAS-stained (B, 400×), Immunofluorescence (C, 200×...
Frozen sections of kidneys from a one year old non-transgenic C57BL/6 mouse and from three thirteen ...
<p><i>129/svj</i> mice were challenged with anti-GBM antibody on day 0 and then treated with hKLK1-M...
<p>(A) Male WT, PAI-1<sup>−/−</sup>, and PAI-1<sup>R101A/Q123K</sup> mice were assessed for kidney i...
<p>(<b>A</b>) The intensity of proteinuria was scored on a 0 to 4 scale. Mean results are shown. (<b...
OBJECTIVE: To investigate the efficacy of different doses of the soluble form of the receptor for a...
<p>(<b>A</b>) Representative images of 4-hydroxy-2-nonenal (4-HNE) immunostaining in the kidneys of ...
<p>(A), Albuminuria data for mice in saline (n=13), Dex (n=13), and P-Dex (n=9) treatment groups is ...