SM934 treatment for 6 months significantly prevented fatal nephritis and prolonged the lifespan.

<p>Six and half months old female NZB/W F₁ mice were orally treated with vehicle, SM934 (10 mg/kg), and PNS (2 mg/kg) for 6 months (n = 12 per group). (A and B), The levels of proteinuria (A) and bodyweight (B) were measured every two weeks. (C) Cumulative survival rate during 6 months of treatment. (D) Histology of representative kidney sections stained with H&E (Original magnification×200). In A, B and C, a = <i>P</i><0.05; b = <i>P</i><0.01; c = <i>P</i><0.001 versus vehicle.