Disease resistance in outbred MF1 mice correlates with strong T regulatory cell responses in the lung.

<p>All results are from intranasal-infection of outbred MF1 mice with wild-type <i>S. pneumoniae</i> D39. (A) Animal disease score at 48 hours p.i. A score of 1 is a normal mouse. Any infected mouse scoring 1 at 48 hours p.i. was considered to have a controlled infection. (B) Number of bacteria/ml blood at 48 hours p.i. CFU=colony forming units. Number of Foxp3⁺ T regulatory cells (C) and Gr-1^hiF4/80^lo neutrophils (D) per mg lung in PBS-treated or <i>S. pneumoniae</i>-infected MF1 mice at 48 hours p.i., as identified in flow cytometry. *'s indicate significant difference, where *=p<0.05 and **=p<0.01. For all graphs data represent mean +/− SEM. Results are representative of 2 independent experiments, each with 3 PBS-treated and >10 infected mice.