The hypermethylation phenotype is maintained in DNMT3B knockout cells.
- Sabine Hagemann (167864)
- Dirk Kuck (167871)
- Carlo Stresemann (167880)
- Florian Prinz (167889)
- Bodo Brueckner (167897)
- Cora Mund (7965)
- Dominik Mumberg (167909)
- Anette Sommer (167915)
Publication date
May 2012
DOIAbstract
<p>(A) Heatmap based on Infinium 27 k data illustrating the methylation levels of 67 CIMP marker genes in HCT-116 colon cancer cells and HCT-116 DNMT3B knockout cells (3BKO). (B) Boxplot illustrating methylation levels of 67 CIMP marker genes. Lines in boxes denote medians, boxes the interquartile range, and whiskers the 2.5th and 97.5th percentiles, respectively. (C) Heatmap based on Infinium 27 k data illustrating the methylation levels of 543 hypermethylated PRC2 target genes in HCT-116 colon cancer cells and HCT-116 DNMT3B knockout cells (3BKO). (D) Boxplot illustrating methylation levels of PRC2 target genes. AVB, Average Beta value.</p
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