DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines-4

<p><b>Copyright information:</b></p><p>Taken from "DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines"</p><p>http://www.molecular-cancer.com/content/7/1/15</p><p>Molecular Cancer 2008;7():15-15.</p><p>Published online 25 Jan 2008</p><p>PMCID:PMC2246151.</p><p></p>ected to unsupervised cluster analysis based upon the mRNA expression of six genes (, and ) which define the hypermethylator phenotype. Four tumors failed to cluster and were excluded from further analysis. Gene designations are depicted vertically and tumor designations are shown horizontally. Four clusters (designated A-D) were identified: Cluster A (majority of which are luminal), Cluster B (majority Her2+), Cluster C (majority luminal), and Cluster D (all basal-like). The expression level for each gene is shown relative to the median expression of that gene across all samples, with high expression shown in red and low expression shown in green, while genes with median expression are shown in black. Tumors were classified as luminal A or luminal B (shown in blue), Her2+ (shown in purple), basal-like (shown in red), or normal-like (shown in green)