Distribution and likelihood analysis.

<p>(A) Distribution of Ctx resistance levels (IC99.99) of 48 beneficial mutants. (B) Likelihood analysis of the estimated shape parameter (<i>κ</i>_e). <i>κ</i>_e is plotted against the number of beneficial mutants (ranked by their effect) that were included for the estimation (<i>n</i>) by using a fitness threshold (<i>w</i>_c). Because each value of <i>n</i> corresponds to a range of values for <i>w</i>_c, there is also a range of <i>κ</i>_e associated with every <i>n</i>. The dashed line corresponds to <i>κ</i> = 0. <i>κ</i>_e is well above zero in the whole depicted range, suggesting that the distribution belongs to the Fréchet domain. (<b>C</b>) The <i>P</i>-value corresponding to the hypothesis <i>κ</i> = 0 is plotted against <i>n</i>. For all choices of <i>w</i>_c and <i>n</i>>14 the null hypothesis can be rejected with more than 95% confidence as indicated by the dashed line.