<p>This figure is a schematic showing how the distribution of fitness effects of beneficial mutations can change depending on the absolute fitness of the wild type (shown with vertical lines) in two different arbitrary distributions of mutational effects on fitness. Note that the distribution of fitness effects of beneficial mutations is very similar in both of these distributions when the fitness of the wild-type is high (short dashed line).</p
Very little is known about the distribution of mutational effects on organismal fitness, despite the...
<p>Sufficiently weakly selected mutations are described by the infinitesimal limit analyzed here, wi...
The rates and properties of newmutations affecting fitness have implications for a number of outstan...
<p>This schematic shows the fates (“fix”, fixation; “ext” extinction) of mutations with different se...
<p>Plotted points show <i>w<sub>i,j</sub></i>, the difference in fitness between beneficial mutation...
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that ...
<p>Regions where mutations have recessive effects (0< <i>h</i><0.5) are shown in gray and additive e...
Characterizing the distribution of fitness effects (DFE) for new mutations is central in evolutionar...
<div><p>(A) Mutations that were initially deleterious and ultimately fixed tended to become benefici...
Adaptation of asexual populations is driven by beneficial mutations and therefore the dynamics of th...
Recent models of adaptation at the DNA sequence level assume that the fitness effects of new mutatio...
Beneficial mutations are intuitively relevant to understanding adaptation [1-3], yet not all benefic...
Mutation is the ultimate source of genetic variability. However, a large fraction of mutations reduc...
When are mutations beneficial in one environment and deleterious in another? More generally, what is...
We extend our previous work on the fitness effect of the fixation of deleterious mutations on a popu...
Very little is known about the distribution of mutational effects on organismal fitness, despite the...
<p>Sufficiently weakly selected mutations are described by the infinitesimal limit analyzed here, wi...
The rates and properties of newmutations affecting fitness have implications for a number of outstan...
<p>This schematic shows the fates (“fix”, fixation; “ext” extinction) of mutations with different se...
<p>Plotted points show <i>w<sub>i,j</sub></i>, the difference in fitness between beneficial mutation...
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that ...
<p>Regions where mutations have recessive effects (0< <i>h</i><0.5) are shown in gray and additive e...
Characterizing the distribution of fitness effects (DFE) for new mutations is central in evolutionar...
<div><p>(A) Mutations that were initially deleterious and ultimately fixed tended to become benefici...
Adaptation of asexual populations is driven by beneficial mutations and therefore the dynamics of th...
Recent models of adaptation at the DNA sequence level assume that the fitness effects of new mutatio...
Beneficial mutations are intuitively relevant to understanding adaptation [1-3], yet not all benefic...
Mutation is the ultimate source of genetic variability. However, a large fraction of mutations reduc...
When are mutations beneficial in one environment and deleterious in another? More generally, what is...
We extend our previous work on the fitness effect of the fixation of deleterious mutations on a popu...
Very little is known about the distribution of mutational effects on organismal fitness, despite the...
<p>Sufficiently weakly selected mutations are described by the infinitesimal limit analyzed here, wi...
The rates and properties of newmutations affecting fitness have implications for a number of outstan...