<p>Estimated resistance factors (on a logarithmic scale, log RF, column 2) and fitness costs (column 3) of TAM-1 and TAM-2 mutants and two mixed mutants arising during ZDV therapy. In parentheses, are the 95% confidence intervals for the estimates obtained from 200 bootstrap samples (where we resampled with replacement from the list of statistical waiting times and re-estimated fitness costs).</p><p>Estimated fitness costs for ZDV mutants.</p
HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know l...
<p>Most synonymous mutations (<i>left panel</i>) have very low selection coefficients. For non-synon...
<p>(A) Experimental scheme to estimate evolutionary compensation of gene defects. See text for detai...
<p>Estimated resistance factors (on a logarithmic scale, log RF, column 2) and fitness costs (column...
<p><b>A</b>. Estimated fitness costs (normalized by setting fitness cost of wild type to 0), <b>B</b...
<p>The predicted probability of the establishment of drug resistance mutations from standing genetic...
In order to develop a better understanding of the evolutionary dynamics of HIV drug resistance, it i...
<p><b>A</b>) Relative fitness of the 21 viable mutants in CEMx174 cells. Values shown are an average...
<p><b>A</b>. Absolute abundance (in numbers) of the 70R mutation. <b>B</b>. Relative abundance of th...
<p>(A) Distribution of Ctx resistance levels (IC99.99) of 48 beneficial mutants. (B) Likelihood anal...
<p><b>(A)</b> A schematic illustrating how a non-preexisting mutant, A’B’, fully resistant to a comb...
(A) Time to emergence of motile zone (days) for first- and second-step mutants in the ΔfleQΔntrC and...
<p>For each treatment, we estimate evolvability as the number of rifampicin-resistant mutants in the...
Mutational load is the depression in a population's mean fitness that results from the continual inf...
<p>(A) Schematic view of engineered deletion mutants. Each arc represents the deleted region in the ...
HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know l...
<p>Most synonymous mutations (<i>left panel</i>) have very low selection coefficients. For non-synon...
<p>(A) Experimental scheme to estimate evolutionary compensation of gene defects. See text for detai...
<p>Estimated resistance factors (on a logarithmic scale, log RF, column 2) and fitness costs (column...
<p><b>A</b>. Estimated fitness costs (normalized by setting fitness cost of wild type to 0), <b>B</b...
<p>The predicted probability of the establishment of drug resistance mutations from standing genetic...
In order to develop a better understanding of the evolutionary dynamics of HIV drug resistance, it i...
<p><b>A</b>) Relative fitness of the 21 viable mutants in CEMx174 cells. Values shown are an average...
<p><b>A</b>. Absolute abundance (in numbers) of the 70R mutation. <b>B</b>. Relative abundance of th...
<p>(A) Distribution of Ctx resistance levels (IC99.99) of 48 beneficial mutants. (B) Likelihood anal...
<p><b>(A)</b> A schematic illustrating how a non-preexisting mutant, A’B’, fully resistant to a comb...
(A) Time to emergence of motile zone (days) for first- and second-step mutants in the ΔfleQΔntrC and...
<p>For each treatment, we estimate evolvability as the number of rifampicin-resistant mutants in the...
Mutational load is the depression in a population's mean fitness that results from the continual inf...
<p>(A) Schematic view of engineered deletion mutants. Each arc represents the deleted region in the ...
HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know l...
<p>Most synonymous mutations (<i>left panel</i>) have very low selection coefficients. For non-synon...
<p>(A) Experimental scheme to estimate evolutionary compensation of gene defects. See text for detai...