<p><b>A</b>. Absolute abundance (in numbers) of the 70R mutation. <b>B</b>. Relative abundance of the 70R mutation in the viral population. The transient appearance and eventual fixation of the mutation 70R can be seen. <b>C</b>. Absolute abundance (in numbers) of mutant genotypes containing the mutation 70R. The absolute abundance of a certain mutation is calculated by adding all mutant genotypes containing the mutation.</p
<p>A: Gene location of mutations. Data are represented as the percentage of the total coding region ...
<p>For our model target, the transition probability (P<sub>mut</sub>) as a function of the number of...
a<p>The viral populations are those described in <a href="http://www.plosone.org/article/info:doi/10...
<p>Dark grey are populations evolved in the benign environment and light grey are the populations ev...
<p><b>A</b>. Estimated fitness costs (normalized by setting fitness cost of wild type to 0), <b>B</b...
<p>(A) The majority of viruses in a wild-type population has few mutations and is viable Some viruse...
The cumulative mutant virus load increases with mutation rate u1 before reaching a peak and then dec...
<p>Mutations generated via virus- and cell-dependent mechanisms can differentially impact viral fitn...
Although the frequency and effects of neutral and nearly neutral mutations are critical to evolution...
<p>(A) HeLa cells, treated with 200 µM or 400 µM ribavirin, or left untreated, were infected at an M...
<p>Distribution of the growth phenotype of all 348,300 single gene knock-out mutants.</p
<p>Mean number of mutations by treatment, with error bars giving +/−1 SE. In the “scfm+mucin+Cip” tr...
Abstract Variation from new mutations is important for several questions in quantitative genetics. K...
A fitness landscape showing three genotypes on different places on the landscape (A, B, and C) and a...
<p>M82 mutant population was screened for mutations in the listed genes. The total size of the scree...
<p>A: Gene location of mutations. Data are represented as the percentage of the total coding region ...
<p>For our model target, the transition probability (P<sub>mut</sub>) as a function of the number of...
a<p>The viral populations are those described in <a href="http://www.plosone.org/article/info:doi/10...
<p>Dark grey are populations evolved in the benign environment and light grey are the populations ev...
<p><b>A</b>. Estimated fitness costs (normalized by setting fitness cost of wild type to 0), <b>B</b...
<p>(A) The majority of viruses in a wild-type population has few mutations and is viable Some viruse...
The cumulative mutant virus load increases with mutation rate u1 before reaching a peak and then dec...
<p>Mutations generated via virus- and cell-dependent mechanisms can differentially impact viral fitn...
Although the frequency and effects of neutral and nearly neutral mutations are critical to evolution...
<p>(A) HeLa cells, treated with 200 µM or 400 µM ribavirin, or left untreated, were infected at an M...
<p>Distribution of the growth phenotype of all 348,300 single gene knock-out mutants.</p
<p>Mean number of mutations by treatment, with error bars giving +/−1 SE. In the “scfm+mucin+Cip” tr...
Abstract Variation from new mutations is important for several questions in quantitative genetics. K...
A fitness landscape showing three genotypes on different places on the landscape (A, B, and C) and a...
<p>M82 mutant population was screened for mutations in the listed genes. The total size of the scree...
<p>A: Gene location of mutations. Data are represented as the percentage of the total coding region ...
<p>For our model target, the transition probability (P<sub>mut</sub>) as a function of the number of...
a<p>The viral populations are those described in <a href="http://www.plosone.org/article/info:doi/10...