<i>In vivo</i> cytotoxicity mediated by HPV16-tk pseudovirions and ganciclovir.

<p>C57BL/6 mice (5 per group) were intraperitoneally injected with 1×10⁶ MOSEC-Luc cells per mouse on day 1. Luciferase activity was examined on day 2 as indication of number of tumors in the mice. Mice were injected HPV16-GFP psV (L1 protein 20 µg) or HPV16/HSV-tk psV at a dose of L1 protein (20 µg/mouse) on day 3. Mice were treated daily with ganciclovir at a dose of 50 mg/kg or PBS from day 5 to day 18. Mice were imaged by non-invasive luminescence imaging techniques on day 20. Data shown are representative of 2 experiments performed.