Comparison of the diffusion properties of GABA_AR γ2 and α5 in inhibitory and excitatory synapses.

<p>(A–B) Cumulative probabilities of diffusion coefficients of γ2 and α5 in inhibitory (green, inh) and excitatory synapses (red, exc) <i>vs</i>. the extrasynaptic membrane (black, ex). Note the reduced diffusion of γ2 and α5 in inhibitory and excitatory synapses as compared to the extrasynaptic membrane (KS test, ***p<10⁻³). (C–D) Decreased explored surface area (C, median EA ±25%–75% IQR; KS test, *p<5×10⁻²; ***p<10⁻³) and dwell time (D, mean ± SEM; t-test, ns: not significant, ***p<10⁻³) for γ2 in inhibitory (green) <i>vs</i>. excitatory (red) synapses. In contrast, the dwell time of α5 did not significantly differ in inhibitory (green) and in excitatory (red) synapses.