Influence of the targets of individual miRNAs on the mouse molecular interaction network.

<p>Rows represent individual protein clusters derived from the Pathway Commons interaction network. Each cluster was functionally annotated using Gene Ontology enrichment analysis (Right). The most enriched GO Terms are displayed. Clusters are numbered in descending size order (X#), the number of genes in each cluster are recorded in parentheses. Each column within the heat map represents an individual miRNA target set. Those miRNAs in black represent gene lists that were derived as part of this study, those in red represent gene lists derived from Melton <i>et al. </i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041762#pone.0041762-Melton1" target="_blank">[40]</a> (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041762#s4" target="_blank">Materials and Methods</a>). The ‘all’ list is a combined set of targets represented in any of the lists derived as part of this study. For each target list the number of genes represented in the interaction network are recorded in parentheses. The relative influence of the targets of each miRNA upon each cluster is ascribed according to the number of nodes adjacent to miRNA-targeted nodes, which reside within a given cluster (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041762#s4" target="_blank">Materials and Methods</a>). The purple to yellow gradient reflects increasing miRNA influence. The green numbers represent the number of genes targeted by the specified miRNA within the respective protein cluster.