Gene expression clusters are targeted by distinct miRNA groups.

<p>Scaled expression (mean subtraction and division by standard deviation) levels of mRNA targets and their respective predicted and inversely associated miRNAs were depicted. Pie charts represent the relative number of mRNA targets per miRNA within the respective gene expression cluster. Absolute target numbers per miRNA within the gene expression cluster were given as well. Self-organizing tree algorithm clusters containing up-regulated genes in <b>(A)</b> early (24 h) or <b>(B)</b> late (72 h) myogenic differentiation, and genes which were <b>(C)</b> down-regulated in early or late myogenic differentiation, or <b>(D)</b> down-regulated in later (72 h) myoblast differentiation (72 h data not shown). A list of the outlined miRNA-mRNA relations was deposited in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135284#pone.0135284.s010" target="_blank">S4 Table</a>.