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cesses at post-transcriptional level. While one miRNA can target many mRNAs, a single mRNA can also be targeted by a set of miRNAs. The targeted mRNAs may be involved in different bio-pairs of miRNAs are co-functionally enriched. For a given set of GO term(s), it can also identify involved in. The miRNA–miRNA co-functional relationship can also be saved as a.txt file, which can be used to further visualize the co-functional network by using other software like Cytoscape. MicroRNAs (miRNAs), a class of 20–24 nucleotide small non-NAs hav lved in bio The miRNAs regulate a wide range of cellular functions, and metabolism. It has been hypothesized that a single miR-NA can concurrently down-regulate hundreds of target mRNAs [3] and thus affect the expression of numerous genes at one time. Functionally related genes are usually regulated by a group of miRNAs instead of one miRNA. The down-reg-ulation of a candidate target by a set of miRNAs depends on how many and which miRNAs are expressed in the cell at a given time. However, recent studies indicate that a relatively small number of miRNAs can set up remarkably complex * Corresponding author