<p>Histograms show the number of DUBs whose knockdown led to phenotype at each stage. A) sqh-Gal4 (ubiquitous) driver; details in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043112#pone-0043112-g003" target="_blank">Figure 3</a>. B) strong elav-Gal4 (pan-neuronal) driver; details in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043112#pone-0043112-g005" target="_blank">Figure 5</a>. In cases where two different RNAi lines targeting the same DUB led to phenotype in different stages, only the earlier stage was counted. Instances where knockdown of a specific DUB by one RNAi line led to defects in two stages were counted for each stage (e.g. knockdown of CG3416 led to death in both larval and...
The technique to arrest Drosophila melanogaster embryos at a specific developmental stage is desirab...
<p>(A) Screening program. In the primary screen, lethality, phototaxis and external eye morphology w...
<div><p>The specificities of the MOs used to define this phenotypic class were investigated by injec...
<p>Listed are the strongest phenotypes associated with ubiquitous knockdown of individual fly DUBs. ...
<p>Progeny from (A) <i>dGyk</i>-IR-let and (B) <i>dGK</i>-IR-let flies result in larvae with melanot...
<p>(A) <i>Act5c dsitpr</i> larvae (<i>Act5cGAL4</i>/<i>UASdsitpr<sup>1063</sup></i>) did not undergo...
<div><p>A. Embryonic lethality sorted by Gene Ontology. Distribution of all genes sorted by Gene Ont...
<p><b>A</b>) Wild type embryos at stage 40/41. <b>B, C</b>) Sibling embryos injected sub-equatoriall...
<p>List of phenotypes observed when individual fly DUBs were knocked down by pan-neuronal drivers wi...
<p>*PUBB2 P61 x HWE embryos (G<sub>0</sub>) were injected with CRISPR/Cas9 RNA constructs.</p><p>**G...
<p>A) The RNA level of the gene corresponding to each ASO was measured (compared to WT, normalized t...
<p>Confocal images were taken of embryos from a worm strain expressing GFP-PH <sup>PLC1delta1</sup>;...
<p>(A) The upper panel shows wild-type seam cell lineages, while the bottom panel indicates the most...
<p><b>(A)</b> Phenotypes of <i>Cyp301a1</i> RNAi driven by the <i>tubulin-</i>GAL4 driver were chara...
<p>(A) Larval hatching of <i>gfp(RNAi)</i>-treated, <i>Pd-rps-2(RNAi)</i>-treated and <i>Pd-dhc(RNAi...
The technique to arrest Drosophila melanogaster embryos at a specific developmental stage is desirab...
<p>(A) Screening program. In the primary screen, lethality, phototaxis and external eye morphology w...
<div><p>The specificities of the MOs used to define this phenotypic class were investigated by injec...
<p>Listed are the strongest phenotypes associated with ubiquitous knockdown of individual fly DUBs. ...
<p>Progeny from (A) <i>dGyk</i>-IR-let and (B) <i>dGK</i>-IR-let flies result in larvae with melanot...
<p>(A) <i>Act5c dsitpr</i> larvae (<i>Act5cGAL4</i>/<i>UASdsitpr<sup>1063</sup></i>) did not undergo...
<div><p>A. Embryonic lethality sorted by Gene Ontology. Distribution of all genes sorted by Gene Ont...
<p><b>A</b>) Wild type embryos at stage 40/41. <b>B, C</b>) Sibling embryos injected sub-equatoriall...
<p>List of phenotypes observed when individual fly DUBs were knocked down by pan-neuronal drivers wi...
<p>*PUBB2 P61 x HWE embryos (G<sub>0</sub>) were injected with CRISPR/Cas9 RNA constructs.</p><p>**G...
<p>A) The RNA level of the gene corresponding to each ASO was measured (compared to WT, normalized t...
<p>Confocal images were taken of embryos from a worm strain expressing GFP-PH <sup>PLC1delta1</sup>;...
<p>(A) The upper panel shows wild-type seam cell lineages, while the bottom panel indicates the most...
<p><b>(A)</b> Phenotypes of <i>Cyp301a1</i> RNAi driven by the <i>tubulin-</i>GAL4 driver were chara...
<p>(A) Larval hatching of <i>gfp(RNAi)</i>-treated, <i>Pd-rps-2(RNAi)</i>-treated and <i>Pd-dhc(RNAi...
The technique to arrest Drosophila melanogaster embryos at a specific developmental stage is desirab...
<p>(A) Screening program. In the primary screen, lethality, phototaxis and external eye morphology w...
<div><p>The specificities of the MOs used to define this phenotypic class were investigated by injec...