<p>Listed are the strongest phenotypes associated with ubiquitous knockdown of individual fly DUBs. Diamonds highlight DUBs whose knockdown led to observable phenotypes. Experimental groups consisted of flies heterozygous for sqh-Gal4 and UAS-RNAi. Controls were heterozygous for sqh-Gal4 on the isogenic background of RNAi lines. “Dead soon after eclosion” category denotes flies that eclosed successfully from the pupal case but fell on food and died within a few hours. Late motility phenotype means it was first observed 20 or more days after eclosing from the pupal case.</p
<p>Percent survival of adult female flies of indicated genotypes at 25°C. Flies had been made coisog...
Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster incl...
(A) Western blot to confirm that dMppedKO is a protein null allele, and expression of dMpped in the ...
<p>List of phenotypes observed when individual fly DUBs were knocked down by pan-neuronal drivers wi...
<p>Histograms show the number of DUBs whose knockdown led to phenotype at each stage. A) sqh-Gal4 (u...
<p>Shown are western blots of whole, newly-eclosed adult flies homogenized in SDS lysis buffer and e...
(A, C) Fraction of dead pupa (in %). A minimum of 6 experimental replicates were analyzed per genoty...
<p>Progeny from (A) <i>dGyk</i>-IR-let and (B) <i>dGK</i>-IR-let flies result in larvae with melanot...
<p><b>A</b>) Percentage flight times of GPCR RNAi heterozygotes (grey) and pan-neuronal knockdowns o...
<p>We knocked down expression of four <i>de novo</i> genes using phiC31 UAS-RNAi lines (see <a href=...
1<p>Few flies survived to the end of DD; refer to <a href="http://www.plosone.org/article/info:doi/1...
Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster incl...
<p>(A) RNAi knock down of <i>dCIA30</i> (<i>dCIA30-</i>RNAi) results in a significant drop in the fr...
<p>Listed are all the fly DUBs that we identified, highlighting previously reported functions and ou...
<p>(A) Development latency. Development time was assessed under 14 conditions (adult stage treatment...
<p>Percent survival of adult female flies of indicated genotypes at 25°C. Flies had been made coisog...
Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster incl...
(A) Western blot to confirm that dMppedKO is a protein null allele, and expression of dMpped in the ...
<p>List of phenotypes observed when individual fly DUBs were knocked down by pan-neuronal drivers wi...
<p>Histograms show the number of DUBs whose knockdown led to phenotype at each stage. A) sqh-Gal4 (u...
<p>Shown are western blots of whole, newly-eclosed adult flies homogenized in SDS lysis buffer and e...
(A, C) Fraction of dead pupa (in %). A minimum of 6 experimental replicates were analyzed per genoty...
<p>Progeny from (A) <i>dGyk</i>-IR-let and (B) <i>dGK</i>-IR-let flies result in larvae with melanot...
<p><b>A</b>) Percentage flight times of GPCR RNAi heterozygotes (grey) and pan-neuronal knockdowns o...
<p>We knocked down expression of four <i>de novo</i> genes using phiC31 UAS-RNAi lines (see <a href=...
1<p>Few flies survived to the end of DD; refer to <a href="http://www.plosone.org/article/info:doi/1...
Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster incl...
<p>(A) RNAi knock down of <i>dCIA30</i> (<i>dCIA30-</i>RNAi) results in a significant drop in the fr...
<p>Listed are all the fly DUBs that we identified, highlighting previously reported functions and ou...
<p>(A) Development latency. Development time was assessed under 14 conditions (adult stage treatment...
<p>Percent survival of adult female flies of indicated genotypes at 25°C. Flies had been made coisog...
Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster incl...
(A) Western blot to confirm that dMppedKO is a protein null allele, and expression of dMpped in the ...