Antigen-specific EC<sub>50</sub> estimation for anti-PfRH5 and anti-PfAMA1 IgG against short-term-adapted Cambodian parasite isolates.
- Andrew R. Williams (124412)
- Alexander D. Douglas (124414)
- Kazutoyo Miura (35285)
- Joseph J. Illingworth (124416)
- Prateek Choudhary (124417)
- Linda M. Murungi (124418)
- Julie M. Furze (124419)
- Ababacar Diouf (69321)
- Olivo Miotto (36337)
- Cécile Crosnier (5648827)
- Gavin J. Wright (121201)
- Dominic P. Kwiatkowski (106264)
- Rick M. Fairhurst (124424)
- Carole A. Long (35289)
- Simon J. Draper (124426)
Publication date
November 2012
DOIAbstract
<p>Dose-response curves were fitted to all GIA versus antigen-specific antibody concentration data for <b>A</b>) CP803, <b>B</b>) CP806, <b>C</b>) CP830, <b>D</b>) CP845 and <b>E</b>) CP887 (multiple IgG dilutions for each of five rabbits for PfRH5 and each of four rabbits for PfAMA1). Dashed vertical lines indicate the fitted EC<sub>50</sub> value for anti-PfRH5 IgG (red) or anti-PfAMA1 (black) IgG for that isolate. Each value is the mean of three wells in a single experiment. Red indicates anti-PfRH5 samples; black indicates anti-PfAMA1 samples.</p
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