Inhibitory coverage against laboratory and field isolates.

<p>(<b>A</b>) One-cycle GIA at 1.25 mg/ml total IgG pool from 3 rabbits tested by the NIH pLDH assay. GIA of anti-QV was compared to trivalent and bivalent vaccine groups and antibodies against <i>P. berghei</i> AMA1 (PbAMA1) were tested as the negative control. Strains CP803, CP806, CP830, CP845, and CP887 were recent culture adapted Cambodian isolates and HB3, GB4, MT/S1, C2A, W2mef were laboratory strains. Lines are median inhibition across strains. (<b>B</b>) One-cycle GIA at 1 mg/ml total IgG pool from 3 rabbits conducted by the WRAIR flow-cytometric method against 8 parasite strains. (*) indicates, p<0.05; (***) p<0.0001 (corrected for multiple comparisons). (<b>C</b>) Two-cycle GIA at 1 mg/ml pooled IgG conducted by the Burnet Institute flow-cytometric method. Strains CSL-2, HCS-E5, 2006, 2004, XIE were recently culture adapted field isolates from Africa, Asia and isolates E8B07, CAMP, D10, K1, T996 were laboratory strains <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003840#ppat.1003840-Drew1" target="_blank">[43]</a>.