Regions in the N and C termini of DmRecQ4 are both required for complete rescue of dsRNA reduction of the endogenous protein.

<p>A) Control cells (S2) and cells expressing full length (FL), C terminal (C) and N terminal (N) fragments of DmRecQ4 were challenged with dsRNA corresponding to the N (NRecQ4) and C (CRecQ4) terminal regions and the proliferation of the cells measured by performing a cell count on days 3, 5 and 7. B) Cells expressing full length, C terminal (C) and N terminal (N) fragments of DmRecQ4 as shown were challenged with dsRNA corresponding to the C terminal regions of DmRecQ4and the cell cycle profile of the cells measured by performing FACS analysis on days 0,3, 5 and 7.