T₃ Response in HepG2 cells.

<p><b>A–D</b>. Numbers of genes that meet cut-offs for fold induction and statistical significance in parental HepG2, HepG2-TRα or HepG2-TRβ at each time point, <b>A</b>, 3 hr, <b>B</b>, 6 hr, <b>C</b>, 24 hr, <b>D</b>, all three time points combined. T₃ induced genes are represented in upper panels (red) and T₃ repressed genes in lower panels (blue), note the difference in scale which means that many more genes are positively regulated than negatively regulated. <b>E–H</b>. Plots of fold induction/repression by T₃ in the presence of TRβ (y-axis) versus TRα (x-axis). <b>E</b>, 3 hr blue, <b>F</b>, 6 hr green, <b>G</b>, 24 hr red, <b>H</b>, all three time points.