Heatmap to Illustrate Patterns of T₃ Response in HepG2.

<p><b>A</b>. Representation of changes in all T₃-dependent genes that meet cutoffs for fold induction/statistical significance in HepG2 parental cells and HepG2-TRα or HepG2-TRβ cells at each time point. Red, upregulated, green, downregulated, black, no change. Genes were clustered according to similarities in response patterns as described in Methods. <b>B</b>. As for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052407#pone-0052407-g003" target="_blank">Fig. 3A</a>, with a section of the heatmap expanded to reveal one of the clusters of late emerging TRβ-preferential T₃ responses.