<p>A) Dyrk1A (red) was found in neuromuscular synapses, where it was not co-localized with α-bungarotoxin (αBtx; green) in wild type (upper panel) and TgDyrk1A (middle panel) mice, indicating that Dyrk1A is located in the presynaptic region. Lower panel depicts pre-absorption experiments against mouse anti-Dyrk1A antibody. B-C) Intensity values (arbitrary pixel intensity units) for Dyrk1A (red) and αBtx (green), a marker of acetylcholine receptors, fluorescence were plotted along a line traced over a synaptic fold in individual endplates on (B) TgDyrk1A mice and (C) pre-absorbed antibody. D) Dyrk1A (red, upper left panel) was present at the pre-synaptic site of the neuromuscular junctions, showed by triple fluorescence immunohistochemistry....
article scientifique soumisChromosome 21 DYRK1A kinase has long been associated with a variety of ps...
Down syndrome (DS), or trisomy 21, is often characterized in humans by motor dysfunctions, muscle we...
Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor ...
<p>A) At PD10, Dyrk1A expression started to be detected in MTNs of the spinal cord (left panel), whe...
<p>A, D) Collapsed low magnification images of confocal z-stacks of coronal sections (16 µm) of the ...
<p>Forty micrometer sections of the mouse brain tissues were incubated with polyclonal anti-Dyrk1A (...
<p>E-18 rat hippocampal neurons were differentiated, fixed with 2% formaldehyde, and immunostained w...
The syntrophins are a family of structurally related proteins that contain multiple protein interact...
<p>Axotomies of wild type and TgDyrk1A mice were performed, sacrificing mice at different time point...
The pattern of innervation of the vertebrate neuromuscular junction is established during early deve...
<p>In order to test if the punctate distribution of Dvl-1 (A) is associated with synapses, we double...
In normal skeletal muscle, the protein dystrophin is associated with plasma membrane glycoproteins a...
Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor ...
Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor ...
(A) Genetic ablation of Schwann cells, similar to erbB inactivation, leads to developmental synaptic...
article scientifique soumisChromosome 21 DYRK1A kinase has long been associated with a variety of ps...
Down syndrome (DS), or trisomy 21, is often characterized in humans by motor dysfunctions, muscle we...
Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor ...
<p>A) At PD10, Dyrk1A expression started to be detected in MTNs of the spinal cord (left panel), whe...
<p>A, D) Collapsed low magnification images of confocal z-stacks of coronal sections (16 µm) of the ...
<p>Forty micrometer sections of the mouse brain tissues were incubated with polyclonal anti-Dyrk1A (...
<p>E-18 rat hippocampal neurons were differentiated, fixed with 2% formaldehyde, and immunostained w...
The syntrophins are a family of structurally related proteins that contain multiple protein interact...
<p>Axotomies of wild type and TgDyrk1A mice were performed, sacrificing mice at different time point...
The pattern of innervation of the vertebrate neuromuscular junction is established during early deve...
<p>In order to test if the punctate distribution of Dvl-1 (A) is associated with synapses, we double...
In normal skeletal muscle, the protein dystrophin is associated with plasma membrane glycoproteins a...
Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor ...
Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor ...
(A) Genetic ablation of Schwann cells, similar to erbB inactivation, leads to developmental synaptic...
article scientifique soumisChromosome 21 DYRK1A kinase has long been associated with a variety of ps...
Down syndrome (DS), or trisomy 21, is often characterized in humans by motor dysfunctions, muscle we...
Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor ...