Effects of oligopeptide HSDCIF on the viability of PAC1-CHO cells as measured by MTT assay (A).

<p>Data are presented as means ±S.E. obtained from six independent experiments. *p< 0.01 HSDCIF groups vs. control group, #p< 0.01, PACAP groups vs. control group. As shown, exogenous HSDCIF had contrary effects with PACAP on the cell viability. Effects of oligopeptide HSDCIF (100 nM) on the activity of PACAP with gradient concentrations (B). Data are presented as means ±S.E. obtained from six independent experiments. $p< 0.01 HSDCIF(100 nM)+PACAP groups vs. PACAP groups. Effects of oligopeptide HSDCIF with gradient concentrations on the activity of PACAP(100 nM) (C). Data are presented as means ±S.E. obtained from six independent experiments. &p< 0.01 HSDCIF+PACAP(100 nM) groups vs. PACAP(100 nM) group. As shown, exogenous HSDCIF decreased the effects of PACAP on the cell viability significantly.