Top 40 methylation loci with statistically significant methylation-expression correlations using the <i>discretization approach</i>.

<p>Additionally, loci in common with the Pearson correlation method are shown in parentheses.</p>*<p>(−) indicates a negative methylation-expression correlation, where high methylation correlates to lower expression or vice versa. (+) indicates a positive correlation where high methylation correlates to increased expression or vice versa.</p>†<p>P values were obtained after 10,000 random permutations of each class label.</p>‡<p>Gene was selected for further validation.</p>§<p>The methylation level of the probe FRZB_P406_F has a positive correlation with gene expression by both Pearson correlation and the discretization method, while the other probe FRZB_E186_R has a negative methylation-expression correlation by both methods. Only the FRZB_P406_F probe is shown for the discretization method due to its statistical significance.