Correlation of expression to intra-gene methylation architecture, for matched BRCA samples.

<p>Expression was taken as the response variable, with one of mean -score, mean derivative and methylation variance as one covariate predictor, together with mean methylation as a second covariate predictor. (a) The proportion of genes with at least one covariate significant (FDR ), and the proportion of genes with neither covariate significant. (b) The proportion of significant genes (i.e., the proportion of the genes represented by the left of each pair of bars in a) which are significant due to one, or the other, or both covariates. For the genes which are significant due to only one covariate predictor, the proportions of these genes for which the significance is due to positive or negative correlation are indicated on the bars with/and \ respectively. There are many genes with expression not significantly predicted by mean methylation but significantly predicted by mean -score, mean derivative, or methylation variance.