<p>The differentially methylated CpGs that matched to differentially expressed genes are sorted above based on the direction with which gene expression correlated with methylation. A positive correlation indicates that hypermethylation matched with upregulation or hypomethylation matched with gene repression. A negative correlation indicates that hypermethylation matched to a repressed gene or that hypomethylation matched to an unregulated gene. The last column shows the ratio of negatively to positively correlated CpGs for each subgroup in the first column.</p
<p>Values are Person’s correlation coefficients and probabilities for the relationship between methy...
<p>All CpGs are ordered from 5’ to 3’. Y axis shows the difference in mean beta values of exposed an...
<p>A) Overview of possible scenarios. If the associations are fully explained (caused) by the SNPs, ...
<p>The matched CpGs are sorted by their genomic context and then based upon the direction with which...
<p><b>Genes were grouped into 50 bins, in order of increasing gene expression. DNA methylation of th...
<p>(A) Pearson correlation was used to measure linear relationships between DNA methylation and gene...
<p>Additionally, loci in common with the Pearson correlation method are shown in parentheses.</p>*<p...
<p>Expression was taken as the response variable, with one of mean -score, mean derivative and methy...
<p>A significant positive correlation was observed between LacZ and CpG % methylation with a p < 0.0...
<p>(A) Pairwise plots of CG (left), CHG (middle), and CHH (right) methylation levels (Y-axis, D homo...
3a)– 3c) show the significant inverse correlation between gene expression for one probe on BCAT1 (22...
*<p>Average correlation is shown for loci with more than one gene expression probe.</p
<p>A correlation analysis was performed on change in methylation and change in gene expression betwe...
A: Analysis in the HbSS group. i PTGFR; ii GPR56; iii GALR2 and iv ADCY4. B: Analysis in the HbSC gr...
<p>(A) Hierarchical clustering of differentially methylated promoters. Z-scored methylation levels a...
<p>Values are Person’s correlation coefficients and probabilities for the relationship between methy...
<p>All CpGs are ordered from 5’ to 3’. Y axis shows the difference in mean beta values of exposed an...
<p>A) Overview of possible scenarios. If the associations are fully explained (caused) by the SNPs, ...
<p>The matched CpGs are sorted by their genomic context and then based upon the direction with which...
<p><b>Genes were grouped into 50 bins, in order of increasing gene expression. DNA methylation of th...
<p>(A) Pearson correlation was used to measure linear relationships between DNA methylation and gene...
<p>Additionally, loci in common with the Pearson correlation method are shown in parentheses.</p>*<p...
<p>Expression was taken as the response variable, with one of mean -score, mean derivative and methy...
<p>A significant positive correlation was observed between LacZ and CpG % methylation with a p < 0.0...
<p>(A) Pairwise plots of CG (left), CHG (middle), and CHH (right) methylation levels (Y-axis, D homo...
3a)– 3c) show the significant inverse correlation between gene expression for one probe on BCAT1 (22...
*<p>Average correlation is shown for loci with more than one gene expression probe.</p
<p>A correlation analysis was performed on change in methylation and change in gene expression betwe...
A: Analysis in the HbSS group. i PTGFR; ii GPR56; iii GALR2 and iv ADCY4. B: Analysis in the HbSC gr...
<p>(A) Hierarchical clustering of differentially methylated promoters. Z-scored methylation levels a...
<p>Values are Person’s correlation coefficients and probabilities for the relationship between methy...
<p>All CpGs are ordered from 5’ to 3’. Y axis shows the difference in mean beta values of exposed an...
<p>A) Overview of possible scenarios. If the associations are fully explained (caused) by the SNPs, ...