RTD-1 increases survival in a mouse model of polymicrobial sepsis.

<p>CLP was performed as described in <i>Methods</i> and animals were treated with i.v saline 4 h post CLP surgery, (•, n = 10), 5 mg/kg RTD-1 4 h post-CLP surgery (▴, n = 11), or RTD-1 24 h after CLP surgery (▪, n = 5). Endpoint survival data are plotted and were subjected to χ² analysis and statistical significance are indicated with * for <i>P</i><0.05 and ** for <i>P</i><0.001.