RTD-1 increases survival in <i>E. coli</i> peritonitis and modulates cytokine/chemokines.

<p><b>A</b>. BALB/c mice were challenged with 8×10⁸ CFU <i>E. coli</i> K12 and treated simultaneously with s.c. injection of saline (•; n = 13) or 5 mg/kg RTD-1 (▴; n = 13). Endpoint survival data are plotted and were subjected to χ² analysis and <i>P</i>-value was ≤0.017 *) by day 3 or later. <b>B</b>. Plasma cytokines/chemokines were quantified in blood obtained from animals euthanized (n = 4 for each time point) at 0, 2, 4, and 12 h after i.p. challenge and treatment with saline (•) or 5 mg/kg RTD-1 (○). Sham controls were injected with RTD-1 alone (▾). Cytokines/chemokines were quantified as described in <i>Methods</i> and results subjected to Student’s <i>t</i>-test; <i>P</i>≤0.05 (*).