Survival experiments in CLP: the role of hypertonic saline solution treatment.

<p>CLP was induced in mice, three groups were analyzed: 1- CLP without any treatment; 2- CLP with normal saline 0.9% treatment; and 3- CLP treated with hypertonic saline solution 7.5% (n = 30 in each group). The animals were observed for 7 days, and mortality was recorded every 12h. We observed that the group treated with hypertonic solution had a better survival rate (60%), in comparison with CLP-S group (46.66%) and C group (33.33%) in the end of the seventh day. No change in mortality was observed after Day 5 in either experimental group. *<i>p</i><0.05, Log-Rank test.