Assessment of spatial learning in the Morris watermaze.

<p>Learning was assessed by the latency in seconds to find the hidden platform. Animals with DS who prenatally received saline (placebo, open circles) did not learn over the 5 day period. Control animals (open squares) who prenatally received saline (placebo) did learn with an approximate halving of their latency. Control animals who prenatally received NAP+SAL (closed squares) also learned over the five day period. Animals with DS who prenatally received NAP+SAL (closed circles) learned over the five day period, similar to controls and significantly better than DS-placebo (p<0.01).