<i>Tspan6</i> mice show normal behavior in the Morris water maze test.

<p>Mice were trained in the hidden platform Morris water maze for 10 days (4 trials/day) and tested with a probe trial (100s) on day 6 and 11. <b>(A)</b> Curve shows no differences between <i>Tspan6</i> KO and WT mice in the learning-related decrease in escape latency (time required to find the platform) during the acquisition phase. <b>(B)</b> Probe trial performance illustrate spatial memory for the platform position as both groups show a preference for the quadrant where the platform was located during the training (target quadrant) with no significant differences between the groups. <b>(C)</b> Spatial learning was analyzed in more detail quantifying the time that the mice spend swimming in the specific area of the quadrant were the platform was during the training showing no changes in the KO animals compared to controls. <i>n</i> = 12 WT, 21 KO animals.