Visuo-spatial learning in the Morris water maze.

<p>Morris water maze performance of Tg<i>RCAN1</i> and wild type animals during the learning sessions expressed as (<b>left panel</b>) latency (s) to reach the platform along the acquisition phase, cue and reversal sessions. A clear deficit was observed in Tg<i>RCAN1</i> in all learning phases; (<b>Right panel</b>) Cumulative search-error on training trials and a learning index (Gallagher's proximity index) computed from the trials over the course of training. This measure relies on a computation of distance from the platform during the trial <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017010#pone.0017010-Arque1" target="_blank">[17]</a> and clearly indicated the use of poorer learning strategies in transgenic mice. White squares represent wild types and black squares represent Tg<i>RCAN1</i>. Data are represented as mean ± S.E.M. *P<0.05, **P<0.01.