Changes in ATP-linked and proton leak OCR in response to 2 hr exposure to rotenone, MPP⁺ and 6-OHDA.

<p>After exposure to rotenone (A), MPP⁺ (B), and 6-OHDA (C) for 2 hr, OCRs were measured after injection of oligomycin (O), FCCP (F) and antimycin A (A). ATP-linked OCR was plotted for rotenone at 0, 0.1, 1, 10 and 100 nM (D), MPP⁺ at 0, 0.005, 0.5, 5 and 500 µM (E), and 6-OHDA at 0, 50, 100 and 200 µM (F); and proton leak OCR for rotenone (G), MPP⁺ (H), and 6-OHDA (I) over the same ranges of increasing doses of neurotoxins as in panels D–F. Data are expressed as percent normalized to OCR before injection of rotenone, MPP⁺, and 6-OHDA. Data = mean ± SEM, n = 3. *<i>p</i><0.05, Student <i>t</i>-test compared to 0 µM treatment.