Electron microscopic appearance of liver xenografts.

<p>A) Ultrastructure of GTKO/CD46 liver before excision from the pig. B) (2 h post-reperfusion). Normal appearance of hepatocytes (H) with widespread platelet (P) aggregation and deposition along liver sinusoidal endothelial cells. C) (necropsy, dark area). Red blood cells (R) with fibrin deposition (F) indicating fibrin clots in the sinusoids. D) (necropsy, light area). Platelet, platelet/monocyte and platelet/necrotic cell aggregates along liver sinusoidal endothelial cells, and patchy endothelial cell death. Dashed lines indicate endothelial cells lining the sinusoids. AB = apoptotic body, EC = endothelial cells, F = fibrin, H = hepatocytes, P = platelets, R = red blood cells. The line at the bottom right indicates 2 µm.