Histological lesions in liver at 24 hours of hepatic reperfusion.

<p>(a) I/R(normal): small area of hepatocyte necrosis and coagulative necrosis with neutrophil infiltration. (b) IP-10(normal): slight incipient and coagulative patchy necrosis of isolated hepatocytes. (c) I/R(fatty): extensive and confluent areas of coagulative necrosis, neutrophilic infiltration, and hemorrhage were observed. (d) IP-10(fatty): patchy areas of hepatocyte incipient necrosis and scattered multifocal areas of coagulative necrosis with neutrophil infiltration were observed, similar to (e) IP-15 (fatty). (f) IP-5(fatty) (original magnification ×400): irregular area of hepatocyte incipient necrosis with neutrophil infiltration, similar to (g) IP-8(fatty), the percentage of necrosis was significantly less in preconditioned than in unpreconditioned group. (h) fatty liver: severe fatty infiltration in hepatocytes as contrl. Hematoxylin-eosin(HE) staining; original magnification ×100.