Histopathology (H&E) of (A) healthy (non-transplanted) pig liver, (B) baboon liver 31 days after allotransplantation, and (C–F) WT pig liver after pig-to-baboon xenotransplantation.

<p>A) Histomorphological appearance of a normal pig liver (×100). Distinct envelope of connective tissue surrounding hepatic lobules. B) Baboon-to-baboon allotransplantation (B3408) on post-operative day 31 (×200). Patchy, mild-to-moderate periportal lymphocytic infiltrates. C) WT pig-to-baboon liver xenoTx at 30 min (B16907) (×100). Significant hepatocellular vacuolar change, patchy sinusoidal congestion, and interlobular septal edema. D) WT pig-to-baboon liver xenoTx at 1 h (B16907) (×200). Severe hepatocellular vacuolar change, focal hepatocyte necrosis, and few thrombi. E) WT pig-to-baboon liver xenoTx at 3 h (B16907) (×100). Early coagulative necrosis, significant sinusoidal congestion, and large thrombus. F) WT pig-to-baboon liver xenoTx at 5 h (just before euthanasia) (B16907) (×100). Acute hemorrhagic coagulative necrosis, extensive hemorrhage, and large fibrin thrombi.