Aβ accumulates in fimbria/fornix axons of 2 month-old APP/PS1 mice at 24 hours post CCI.

<p><b>A–C</b>. APP staining in the ipsilateral fimbria/fornix of a sham APP/PS1 mouse (<b>A</b>), an injured APP/PS1 mouse (<b>B</b>), and an injured 3xTg-AD mouse (<b>C</b>). Scale bar: 50 µm. Similar extent of axonal injury as detected by APP staining was seen in injured APP/PS1 and 3xTg-AD mice. <b>D–F</b>. Aβ staining with panAβ antibody. <b>G–I</b>. Aβ staining with HJ3.4 antibody. Histological and stereological quantification showed similar extent of Aβ accumulation in injured APP/PS1 and 3xTg-AD mice: 47,257±11,763 HJ3.4-positive varicosities per cubic mm in APP/PS1 (n = 5) vs. 65,437±8,458 in 3xTg-AD mice (n = 8), Student's t-test, p = 0.23.