Additional file 4: of Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

Figure S3. Callosal Aβ pathology in uninoculated and Aβ-inoculated AppNL-F mice. Brain sections from male AppNL-F mice at the indicated ages that were either injected with partially purified Aβ aggregates (TgCRND8–1 sample) or left uninoculated were subjected to Aβ immunohistochemistry using the 4G8 antibody. In Aβ-inoculated mice, the induced Aβ deposits were found within the subcallosal region whereas in uninoculated mice the Aβ deposits were present within the corpus callosum itself. Scale bars: 20 μm. (TIFF 757 kb