Vi modulates innate immune responses through TLR.

<p>Spleens were removed from naïve, WT or KO animals (both MyD88^−/− and TLR4^−/−) infected with C5.507 (Vi⁺) or SGB1 (Vi⁻) 24 h after infection. The cfu per g of tissue (A) and the percentage of splenocytes that were Ly6G⁺ (B) or DX5⁺/CD3⁻ (C) were determined. Columns represent the percentage of cells ± SEM. Significant differences are indicated * p<0.05; **, p<0.01; ***, p<0.001, and for comparison of Vi⁺ compared to Vi⁻ infected mice, ^†† p<0.01; ^†††, p<0.001, as determined by one-way ANOVA followed by Bonferroni's multiple comparison test. # Colonisation data for two of the mice in the TLR4^−/− mouse group inoculated with C5.507 were not determined.