Adipocyte hypertrophy is blunted in OPN KO mice.

<p>(A) Representative histological images of eWAT from mouse groups. (B) Quantitation of subcutaneous WAT (scWAT) and epididymal WAT (eWAT) adipocyte size. WT scWAT (black bars), WT eWAT (dark grey bars), OPN KO scWAT (light grey bars), OPN KO eWAT (white bars). 7 mice per group. Values are averages ± standard error. * p<0.05 vs diet-matched WT, # p<0.05 vs strain-matched, normal chow. (C) Correlation of eWAT fat pad weight and adipocyte size in HFD-fed WT and OPN KO mice. WT (filled symbols), OPN KO (open symbols). 7 mice per group. (D) GDR normalized to eWAT cell size in HFD-fed WT (black bars) and OPN KO (grey bars) mice. 5–6 mice per group. Values are averages ± standard error. * p<0.05 vs WT.