Densitometric quantitation of soluble oligomeric Aβ.

<p>The levels of pathogenic Aβ oligomers in the brain homogenates were assessed by Western-blot using the A11 oligomer-specific antibody as illustrated on top left of the figure for two representative brain extracts from two pABri vaccinated and two control Tg mice.The A11 ∼42 kDa immunoreactive band was also immunoreactive with anti-Aβ 6E10 monoclonal antibody (top right of figure). No oligomers were detected in wild-type mice (data not shown). A bar graph of the densitometric analysis of the A11 immunoreactive band is shown at the bottom of the figure (two-tailed <i>t-</i>test, *p<0.05).